Cancer Doctors Wield Advanced Tools in Treatment for Mesothelioma, despite the Fact that Prognosis Is Still Grim
July 3rd, 2009
Oncologists decide what type of treatment to pursue with every patient. There are many options. There is no standard treatment regimen for peritoneal mesothelioma patients. Mesotheliomas lack of agreed-upon treatment is due to low a treatment success rate, rareness, a high mortality rate and a small number of studies providing meaningful stats.
Mesothelioma patients have historically had a bleak outlook, but doctors have recently made progress. Traditional treatments for cancer are surgery (removing the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) All three methods have problems. Patients with mesothelioma have not responded well to traditional radiation therapy. Researches, concerned about damage to healthy tissue, are looking for ways to aim radiation directly at tumors.
Surgery removes the mesothelial tissue around the tumor. It is a grueling surgery with unknown benefits to patients. The usual chemotherapy cocktails effective on other cancers are not effective on mesothelioma, and combinations of chemotherapy agents have been tried, but without much success. Like radiation, researchers are focusing their work on controlling the physical location of the treatment with an emphasis on the pleural cavity.
The death rate for mesothelioma is so high that many of even the most sophisticated techniques in cancer treatment are tried out on patients. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. A new drug that has shown results in improving survival is pemetrexed (brand name Alimta).
Considered by oncologists is where the tumor is located, what stage the mesothelioma is in, and the age and health of the patient. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Clinical trials using these techniques are being offered to some of those who have mesothelioma.
